Wednesday, May 13, 2009

Encyclopedia of Biological Chemistry(生物化学百科全书)


Available online 29 October 2004.

William J. Lennarz, State University of New York at Stony Brook, Stony Brook, New York, USA

Section: Lipids, Carbohydrates, Membranes and Membrane Proteins

WILLIAM J. LENNARZ received his B.S. in Chemistry from Pennsylvania State University and a Ph.D. in Organic Chemistry from the University of Illinois. Subsequently he carried out postdoctoral work at Harvard with Konrad Bloch on fatty acid biosynthesis. In 1962 he was appointed Assistant Professor at Johns Hopkins in the Department of Physiological Chemistry. After promotion to Associate Professor in 1967, and full Professor in 1971, he remained at Hopkins until 1983. At that time, he was appointed Robert A. Welch Professor and Chair of the Department of Biochemistry and Molecular Biology at the University of Texas Cancer Center, M.D. Anderson Hospital. In 1989 he became a Leading Professor and Chair of the Department of Biochemistry and Cell Biology at SUNY at Stony Brook. In 1990 he founded and became Director of the Institute for Cell and Developmental Biology at Stony Brook.

Dr. Lennarz has served on many national and international committees. He has served as President of the Biochemistry Chairman's Organization, President of the American Society for Biochemistry and Molecular Biology and President of the Society for Glycobiology. He was a member of the Executive Committee of the International Union of Biochemistry and Molecular Biology for almost a decade.

He has presented special lectures at the University of Notre Dame, the NIH, the University of West Virginia, Johns Hopkins University, Florida State University, the University of California at San Diego, the University of Arkansas, Indiana University and the Medical College of Virginia.

He is a member of the National Academy of Sciences. The focus of his early work was on lipids and bacterial cell surfaces. More recent efforts have been in the structure, biosynthesis and function of cell surface glycoproteins. The biosynthesis studies initially were carried out in liver and oviduct, but these efforts now are focused in yeast. The functional studies have concentrated on the role of cell surface glycoproteins in fertilization and early development in the sea urchin and, more recently, the frog. For over 30 years Dr. Lennarz' research has been supported by federal sources, primarily the National Institutes of Health. Recently he was appointed Distinguished Professor and Chair of his department.

M. Daniel Lane, The Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA

Section: Metabolism, Vitamins and Hormones

M. DANIEL LANE received B.S. and M.S. degrees in 1951 and 1953 from Iowa State University and a Ph.D. in 1956 from the University of Illinois. He was a Senior Postdoctoral Fellow with Professor Feodor Lynen at the Max-Planck Institute Fur Zellchemie in Munich. Following faculty positions at Virginia Polytechnic Institute and New York University School of Medicine, he joined the faculty at the Johns Hopkins University School of Medicine in 1969 and served as DeLamar Professor and Director of the Department of Biological Chemistry from 1978 to 1997. He is presently Distinguished Service Professor at Johns Hopkins. In 2002 he received an honorary degree, Doctor of Humane Letters, from Iowa State University.

Dr. Lane was elected to membership in the National Academy of Sciences (in 1987) and was elected as a Fellow of the American Academy of Arts and Sciences (in 1982) and of the American Society of Nutritional Sciences (in 1996). He received the Mead Johnson Award from the American Society for Nutritional Sciences in 1966 for his research on biotin-dependent enzymes and in 1981, the William C. Rose Award from the American Society for Biochemistry and Molecular Biology for his work on the insulin receptor. In 1990–1991 Lane served as President of the American Society of Biochemistry and Molecular Biology. He has presented many named lectureships (including the Feodor Lynen Lecture in Germany in 1999) and served on numerous editorial boards including the Journal of Biological Chemistry and the Annual Reviews of Biochemistry. Currently he is Associate Editor for Biochemical and Biophysical Research Communications.

Dr. Lane has published 280 research papers in major scientific journals. His early work focused on various enzymatic CO2 fixation reactions, notably the mechanisms by which the B-vitamin, biotin, functions in enzymes to catalyze carboxylation. Dr. Lanes work on the regulation of acetyl-CoA carboxylase, the key regulatory enzyme of fatty acid synthesis, led him to his present interests which are to understand the basic mechanisms of lipogenesis, adipogenesis and the consequence of aberrations in these processes, most notably obesity. Research currently underway in his laboratory focuses on: (1) the genes that signal stem cell "commitment" to the adipocyte lineage and subsequent differentiation into adipocytes, and (2) the mechanisms by which the region of the brain, known as the hypothalamus, monitors and controls the drive to eat.
Download:VOL I.pdf VOL II.pdf VOL III.pdf VOL IV.pdf

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